1 Introduction. Phospholipids are essential components of mammalian cell membranes [].Specifically, phospholipids are distributed asymmetrically between the inner and outer leaflets of the plasma membrane …

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The aim of this study was to investigate the role of human epidermal growth factor receptor (HER3) and PTEN expression in patients with HER2-overexpressing metastatic breast cancer (MBC). One ...

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Phosphoinositide kinases (PIKs) are a group of lipid kinases that are important upstream activators of various significant signaling pathways. Hyperactivation of the PI3K/AKT/mTOR pathways—either via mutations or genomic amplification—confers key oncogenic activity, essential for the development and progression of several solid tumors. …

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Filamentous fungi generally form aggregated hyphal pellets in liquid culture. We previously reported that α-1,3-glucan-deficient mutants of Aspergillus nidulans did not form hyphal pellets and their hyphae were fully dispersed, and we suggested that α-1,3-glucan functions in hyphal aggregation. However, Aspergillus oryzae α-1,3-glucan-deficient (AGΔ) mutants still form …

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PIK3CA is the oncogene showing the highest frequency of gain-of-function mutations in breast cancer, but the prognostic value of PIK3CA mutation status is controversial. We investigated the prognostic significance of PIK3CA mutation status in a series of 452 patients with unilateral invasive primary breast cancer and known long-term outcome (median follow-up 10 …

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PIK3CA mutations represent one of the most common genetic aberrations in breast cancer. They have been reported to be present in over one-third of cases, with enrichment in the luminal and in human epidermal growth factor receptor 2-positive subtypes. Substantial preclinical data on the oncogenic properties of these mutations have been reported.

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Mill scale is an oxide waste product of the steel mills, which contains around 70% iron and other allied impurities. In the present context, a dynamic prototype counter current reactor (CCR) has been used for experimentation and simulation of particle bed by …

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and Keltouma Driouch .....6092 Neutrophil Gelatinase–Associated Lipocalin: ANovel Suppressor of Invasion and Angiogenesis in Pancreatic Cancer. Zhimin Tong, Ajaikumar B. Kunnumakkara, Huamin Wang, Yoichi Matsuo, Parmeswaran Diagaradjane, Kuzhuvelil B. Harikumar,

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The impact of biomass morphology and culture conditions on fungal fermentation was widely reviewed in the literature. In this work, we presented three independent experiments in order to evaluate the influence of some of those input factors on a lipase production separately by using the Aspergillus niger MYA 135 and the two-stage fermentation technique.

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Metalsa will assemble ventilators, contributing to the community in the present pandemic. Providing safe automotive structures to help our customers move the world. Exceeding quality in our services. Our strategic business units consist of heavy trucks, buses, and light vehicles. Trusted by the best.

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George Mills GBR Marseille 628. 3:36.33 Pekka Vasala FIN München (OG) Daniel Zegeye ETH Linz Matthieu Vandiest BEL Bruxelles Robert Domanic USA Azusa Michael Kibet KEN Tomblaine 633. 3:36.34 Paul Rugut KEN München 634. 3:36.35 Brahim Boutayeb MAR Monaco …

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Munkley J, McClurg UL, Livermore KE, Eann I, Knight B, McCullagh P, McGrath J, Crundwell M, Harries LW, Leung HY, Mills IG, Robson CN, Rajan P, Elliott DJ. The cancer-associated cell migration protein TSPAN1 is under control of androgens and its upregulation increases prostate cancer cell migration. Scientific Reports 2017, 7(1), 5249.

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The erbB receptors, including the epidermal growth factor receptor (EGFR), erbB2 (also known as HER2/neu), erbB3 (or HER3), and erbB4 (or HER4), are often aberrantly activated in a wide variety of human cancers. They are excellent targets for selective anti-cancer therapies because of their transmembrane location and pro-oncogenic activity. While several therapeutic …

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Ataxia telangiectasia mutated (ATM) is a kinase that has a central role in the maintenance of genomic integrity by activating cell cycle checkpoints and promoting repair of DNA double-strand ...

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Consequently, it inhibits metastasis and tumor progression through miR-125a-5p transcription and the subsequent inhibition of IP6 K1. In contrast, hormone-responsive breast cancer cells (MCF-7) are insensitive to myo -Inositol. This is due to the persistence of MDM2 synthesis promoted by estrogen-dependent pathways.

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Elevated expression of erbB3 receptor has been reported to induce resistance to therapeutic agents, including trastuzumab in erbB2-overexpressing breast cancer. Our recent studies indicate that erbB3 interacts with both erbB2 and IGF-1 receptor to form a heterotrimeric complex in trastuzumab-resistant breast cancer cells. Herein, we investigate the antitumor …

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